Final answer:
The region where AIDS has killed the largest number of individuals is Sub-Saharan Africa.
Step-by-step explanation:
The region where AIDS has killed the largest number of individuals is Sub-Saharan Africa. Sub-Saharan Africa is home to nearly 70 percent of the world's HIV-positive cases and has the highest number of people infected with HIV and AIDS. It also accounts for the largest number of deaths due to AIDS. Over 20 million people have died from AIDS in this region.