Final answer:
A high H+ concentration can lead to fatigue by affecting Ca++ binding to troponin due to a decrease in intracellular pH, which impairs enzymes and proteins necessary for muscle contraction.d. interfering with Ca++ binding to troponin.
Step-by-step explanation:
A high H+ concentration can contribute to fatigue by interfering with Ca++ binding to troponin. This effect is tied to a decrease in intracellular pH, which affects the activity of enzymes and proteins involved in muscle contraction. When the pH drops, enzymes involved in catalyzing muscle contraction, such as lactate dehydrogenase, become less effective. This in turn can lead to a reduced ability for muscles to contract, as the proper binding and release of calcium which is critical for muscle contraction are impeded.