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The resting metabolic rate decreases in subjects that lose weight on a low-calorie diet. Which of the following factors are contributors to this weight loss-induced decline in resting metabolic rate?

a. a decrease in circulating thyroid hormone
b. reduced sympathetic nervous system activity
c. the loss of fat free mass
d. all of these contribute to the decrease in resting metabolic rate

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Final answer:

The decrease in resting metabolic rate in subjects that lose weight on a low-calorie diet is primarily due to a decrease in circulating thyroid hormone, reduced sympathetic nervous system activity, and the loss of fat free mass.

Step-by-step explanation:

The decrease in resting metabolic rate in subjects that lose weight on a low-calorie diet is mainly due to three factors:

  1. A decrease in circulating thyroid hormone: Thyroid hormone plays a crucial role in regulating metabolism. When weight is lost, the body produces less thyroid hormone, leading to a decrease in metabolic rate.
  2. Reduced sympathetic nervous system activity: The sympathetic nervous system is responsible for increasing metabolic rate. Weight loss can decrease sympathetic activity, resulting in a decline in resting metabolic rate.
  3. The loss of fat free mass: Fat-free mass, such as muscle, requires more energy to maintain compared to fat. When weight is lost, there is often a loss of fat-free mass, which contributes to the decline in resting metabolic rate.

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