Final answer:
The decrease in resting metabolic rate in subjects that lose weight on a low-calorie diet is primarily due to a decrease in circulating thyroid hormone, reduced sympathetic nervous system activity, and the loss of fat free mass.
Step-by-step explanation:
The decrease in resting metabolic rate in subjects that lose weight on a low-calorie diet is mainly due to three factors:
- A decrease in circulating thyroid hormone: Thyroid hormone plays a crucial role in regulating metabolism. When weight is lost, the body produces less thyroid hormone, leading to a decrease in metabolic rate.
- Reduced sympathetic nervous system activity: The sympathetic nervous system is responsible for increasing metabolic rate. Weight loss can decrease sympathetic activity, resulting in a decline in resting metabolic rate.
- The loss of fat free mass: Fat-free mass, such as muscle, requires more energy to maintain compared to fat. When weight is lost, there is often a loss of fat-free mass, which contributes to the decline in resting metabolic rate.