Final answer:
Glycolysis can proceed in the absence of oxygen due to fermentation, which allows for the regeneration of NAD+ and the continuation of glycolysis. This is achieved by converting pyruvate to either lactate or ethanol and carbon dioxide.
Step-by-step explanation:
Glycolysis is the initial step in glucose metabolism and can proceed in the absence of oxygen due to the process of fermentation. During glycolysis, glucose is broken down into two molecules of pyruvate. In the absence of oxygen, pyruvate can be further metabolized through fermentation, which regenerates NAD+ and allows glycolysis to continue. This is achieved by converting pyruvate to either lactate or ethanol and carbon dioxide.