Final answer:
The next step would be to perform a repeat endoscopy with biopsy to evaluate the ulcers and ruling out other causes. H. pylori testing is also important. CT scan or Upper GI series may be considered in specific cases, not as the next immediate steps.
Step-by-step explanation:
The next step in a patient with peptic ulcer disease (PUD) and multiple ulcers and thickened gastric folds on endoscopy would be to perform a repeat endoscopy with biopsy. This is necessary to obtain tissue samples for further evaluation and to rule out other potential causes of the thickened gastric folds. It can help determine the severity of the ulcers, assess healing progress, and guide treatment decisions.
Helicobacter pylori testing is also an important step to consider, as this bacteria is a common cause of PUD. Testing for H. pylori can involve breath tests, blood tests, stool tests, or stomach wall biopsy.
CT scan of the abdomen or Upper GI series may be considered in specific cases if there are concerns about complications or related conditions, but they would not be the next immediate steps in this scenario.