Question

With which cause of macrocytic anemia is elevated MMA associated?

a) Folate deficiency
b) Vitamin B12 deficiency
c) Liver disease
d) Hemolytic anemia

Answer 1

Elevated MMA levels are associated with Vitamin B12 deficiency, which leads to macrocytic anemia.

Step-by-step explanation:

Elevated Methylmalonic Acid (MMA) is most commonly associated with Vitamin B12 deficiency in the context of macrocytic anemia. In cases of Vitamin B12 deficiency, the body lacks sufficient amounts of this nutrient to support the proper formation of red blood cells, leading to the production of larger than normal red blood cells, known as macrocytes, which are inefficient at oxygen transport.

This condition may occur due to inadequate dietary intake, as seen in vegans and vegetarians, or because of poor absorption, as in the case of pernicious anemia, which is often found in patients with gastrointestinal disorders like Crohn's disease or following surgeries that affect the stomach or intestines. In contrast, folate deficiency, while it also causes macrocytic anemia, is not typically associated with elevated MMA levels.