Final answer:
Cells lacking mannose 6-phosphate receptors improperly secrete lysosomal enzymes instead of routing them to the lysosomes, which impairs cellular digestion and waste processing.
Step-by-step explanation:
Cells that are deficient in mannose 6-phosphate receptors have an oversecretion of lysosomal enzymes. These receptors are responsible for tagging lysosomal enzymes within the Golgi apparatus for transportation to the lysosomes. Without these receptors, the enzymes are not properly directed to the lysosomes and are instead secreted out of the cell. This causes a deficiency in the enzymes within the lysosomes, impairing the cell's ability to break down macromolecules.
The production and activation of enzymes like trypsinogen and chymotrypsinogen as inactive proenzymes are crucial for preventing the destruction of the pancreas and small intestine. Trypsinogen, converted to trypsin in the small intestine by enterokinase, then activates other digestive enzymes. However, these processes are not related to the oversecretion issue caused by mannose 6-phosphate receptor deficiency.