Final answer:
Nucleotide triphosphate hydrolysis does not play a role in selecting cargo molecules for vesicle trafficking; instead, specific interactions between cargo and receptor proteins, as well as SNARE protein interactions, are key factors.
Step-by-step explanation:
The factor that has NO contribution to the selection of cargo molecules for vesicle trafficking is the hydrolysis of nucleotide triphosphates to provide energy. While energy is needed for protein trafficking, it is not a selection criteria for cargo molecules. Instead, the selection of cargo molecules primarily depends on the interaction between cargo proteins and specific cargo receptor proteins within the trans Golgi network. Cargo proteins bound to these receptors will be packaged into vesicles that are coated with proteins such as clathrin and COP proteins to form budding vesicles aimed at different destinations.
Another essential factor in the vesicle trafficking process is the interaction between V-SNARE proteins on vesicles and complementary T-SNARE proteins on target membranes, which triggers membrane fusion and the delivery of cargo.