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Congenital marrow failure, poor growth, morphologic abnormalities, and macrocytic anemia:

a) Thalassemia
b) Sickle cell disease
c) Fanconi anemia
d) Hemophilia

User PlagTag
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Final answer:

The condition with congenital marrow failure and macrocytic anemia is Fanconi anemia (c). It is a genetic bone marrow failure syndrome, differing from thalassemia and sickle cell disease which affect the hemoglobin and red blood cell shape, respectively.

Step-by-step explanation:

The condition characterized by congenital marrow failure, poor growth, morphologic abnormalities, and macrocytic anemia is known as Fanconi anemia (c). Fanconi anemia is a rare genetic disorder that affects the bone marrow and results in decreased production of all types of blood cells, including those which are responsible for oxygen transport, leading to anemia.

It is different from thalassemia, which specifically involves the abnormal formation of hemoglobin and destruction of red blood cells, and from sickle cell disease, which causes red blood cells to become sickle-shaped, leading to various complications. Unlike both of these conditions that are also hemoglobinopathies, Fanconi anemia is primarily a bone marrow failure syndrome that can lead to various hematological abnormalities including macrocytic anemia.

Hemophilia, on the other hand, is a genetic disorder characterized by inadequate synthesis of clotting factors and does not involve red blood cell production directly.

User Silv
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