Final answer:
The best route from Columbus Circle to Pennsylvania Station is taking the A or C subway train downtown from 59th Street station to 34th Street-Penn Station, with the trip usually taking about 10 minutes.
Step-by-step explanation:
The best route from Columbus Circle to Pennsylvania Station in New York City primarily depends on the time of day and personal preference for convenience or speed. In general, the most direct public transit option would be to take the subway. You can board the A or C train downtown (towards Brooklyn/Queens) from Columbus Circle (59th Street station) and disembark at 34th Street-Penn Station, which is directly connected to Pennsylvania Station. This trip typically takes about 10 minutes. Alternatively, one could take a bus, taxi, bike, or walk, but these options may take longer or be affected by traffic.