Question

One of the things that help fibroblasts and carcinoma cells to migrate through the extracellular matrix is their ability to degrade (break down) the molecules present in the environment. What do these cells use that help them degrade the environment?

Answer 1

Fibroblasts and carcinoma cells use enzymes called matrix metalloproteinases (MMPs) to degrade molecules in the extracellular matrix (ECM), allowing them to migrate. MMPs break down components such as collagen and proteoglycans, creating a path for cell movement.

Step-by-step explanation:

Fibroblasts and carcinoma cells utilize enzymes called matrix metalloproteinases (MMPs) to degrade the molecules present in the extracellular matrix (ECM). MMPs are secreted by these cells and are capable of breaking down components of the ECM such as collagen and proteoglycans. These enzymes allow the cells to create a path through the ECM, enabling migration to different locations.