Final answer:
Antihistamines and topical steroids typically have fewer side effects compared to systemic corticosteroids or immunosuppressants. Antihistamines block the effects of histamines on allergy symptoms, while topical steroids reduce local inflammation with minimal systemic impact.
Step-by-step explanation:
When comparing the side effects of different treatments, antihistamines and topical steroids generally give fewer side effects than systemic corticosteroids or immunosuppressants. Antihistamines work by preventing histamines, which are released by mast cells, from causing allergy symptoms like itching and swelling. On the other hand, topical steroids, such as hydrocortisone creams, reduce inflammation by suppressing the local immune response in the skin, leading to a decrease in histamine production and resultant symptoms such as pruritus (itching) and rashes. Systemic corticosteroids and immunosuppressants have broader effects on the immune system and can be associated with more significant side effects due to their widespread impact on the body's immunity.