Final answer:
Pruritus Chemical Mediators, such as histamines, are released by mast cells and interact with neurotransmitters causing itching(option a). Cytokines also contribute to the production of inflammatory mediators, which can be blocked by antihistamines to alleviate symptoms.
Step-by-step explanation:
The Pruritus Chemical Mediators responsible for cutaneous itch interact with neurotransmitters(option a).
When a mast cell reacts to an irritation, it releases histamines, which are the chemical mediators that elicit an allergic reaction. These histamines stimulate nerves that lead to the sensation of itching. Additionally, cytokines, which are also released by mast cells, can trigger the production of more mediators like histamine, leukotrienes, and prostaglandins, which further contribute to inflammation and itching. Antihistamines can help by preventing these histamines from stimulating the itching and swelling of body tissues.