Final answer:
The contraction and relaxation of skeletal muscles, also known as the skeletal muscle pump, is a factor that greatly improves venous return to the heart during strenuous exercise (Option C).
Step-by-step explanation:
One of the factors that greatly improves venous return to the heart during strenuous exercise is the contraction and relaxation of skeletal muscles. This mechanism, known as the skeletal muscle pump, increases the pressure in the veins as the surrounding skeletal muscles contract.
This pressure helps blood in the veins overcome gravity and return to the heart, supported by one-way valves that ensure blood flows in the proper direction. Particularly in the legs during activities like walking or running, this muscle pump is essential to prevent blood from pooling in the lower extremities, thereby maintaining efficient circulation.
Thus, the correct option is C.