Final answer:
DNase I hypersensitive sites arise due to certain structural features in DNA that make it more accessible and susceptible to cleavage by DNase I enzyme. These features can be caused by factors such as DNA bending, protein binding, or chemical modifications.
Step-by-step explanation:
DNase I hypersensitive sites arise due to the presence of certain structural features in DNA that make it more accessible and susceptible to cleavage by DNase I enzyme.
These hypersensitive sites can be caused by various factors such as the bending or kinking of the DNA molecule, the binding of specific proteins to the DNA sequence, or the presence of certain chemical modifications on the DNA.
For example, the binding of transcription factors to specific regulatory regions can cause the DNA to unwind and become more exposed, resulting in DNase I hypersensitivity.