Final answer:
Spongiform degeneration/vacuolization is a characteristic feature seen in sporadic Creutzfeldt-Jakob disease (sCJD).
Step-by-step explanation:
Spongiform degeneration/vacuolization in sCJD
Spongiform degeneration/vacuolization is a characteristic feature seen in sporadic Creutzfeldt-Jakob disease (sCJD). It is caused by the abnormal formations of prion protein (PrPSC) in the brain tissue. These abnormal protein complexes lead to the formation of sponge-like lesions, also known as vacuoles, in the brain. The presence of these vacuoles gives the brain a spongy appearance, which is why the disease is called spongiform encephalopathy.