Question

Triptans should not be combined with SSRIs or SNRIs because this could occur:

a) Serotonin syndrome
b) Hypertension
c) Bradycardia
d) Respiratory depression

Answer 1

Combining triptans with SSRIs or SNRIs can result in serotonin syndrome due to the accumulation of excessive serotonin in the synaptic cleft.

Step-by-step explanation:

Triptans should not be combined with SSRIs (Selective Serotonin Reuptake Inhibitors) or SNRIs (Serotonin-Norepinephrine Reuptake Inhibitors) because this could lead to serotonin syndrome, a potentially life-threatening condition. Serotonin syndrome occurs when there is an excess of serotonin in the synaptic cleft, due to SSRIs blocking the reuptake of serotonin into the presynaptic neuron. Triptans share a similar mechanism to SSRIs and SNRIs by also affecting serotonergic pathways, thus increasing the risk of serotonin overload. The combination of these medications should be avoided to prevent excessive serotonin accumulation, resulting in serotonin syndrome.