Final answer:
A suppository for rectal administration should be lubricated with a water soluble lubricant to ease insertion and prevent mucosal irritation, which makes the statement true.
Step-by-step explanation:
True, a suppository given rectally must indeed be lubricated with a water soluble lubricant. This is important to help ease the insertion of the suppository and reduce the risk of mucosal irritation inside the rectum. Water soluble lubricants are preferred as they are less likely to cause damage to the mucosal membranes and are easily absorbed or washed away. By using the correct type of lubricant, the process can be made more comfortable for the patient, and the effectiveness of the drug delivery can be optimized.