Final answer:
Local anesthetics like lidocaine and sedatives such as midazolam or propofol are commonly given before cystoscopy to reduce pain and discomfort and help relax the patient.
Step-by-step explanation:
The drugs most commonly given before cystoscopy include a local anesthetic such as lidocaine and a sedative such as midazolam or propofol. Lidocaine is used to numb the area, reducing pain and discomfort during the procedure. Sedatives help relax the patient and reduce anxiety.