Final answer:
Enzymes assist by decreasing the activation energy and stabilizing the transition state, but do not increase the concentration of reactants.
Step-by-step explanation:
The mechanism by which enzymes assist in the formation of a transition state intermediate that is not correct is option 3) Increasing the concentration of reactants. Enzymes function by decreasing the activation energy of a reaction, stabilizing the transition state, and providing a favorable microenvironment for the reaction. They do not change the concentration of reactants, but instead, they facilitate reactions that would occur at a much slower rate by binding to substrates and lowering the energy barrier for the reaction to proceed.