Final answer:
Leg swelling, breast tenderness, and mood changes are adverse effects of hormone replacement therapy that the nurse should instruct the client to notify the provider about.
Step-by-step explanation:
The nurse should instruct the client to notify the provider for the following adverse effects: leg swelling, breast tenderness, and mood changes. Although weight gain, headache, and other side effects can occur with hormone replacement therapy, the nurse should specifically instruct the client to notify the provider for these three adverse effects as they could indicate more serious complications.