Final answer:
The second step in the World Health Organization's 3-step ladder for pain management involves the use of opioid analgesics, which are prescribed when over-the-counter pain relievers like acetaminophen or NSAIDs fail to control pain.
Step-by-step explanation:
The second step in the World Health Organization's 3-step ladder for pain management is to use opioid analgesics. When over-the-counter (OTC) medicines such as acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs) do not adequately relieve pain, a physician may prescribe stronger medications like opioids. Opioids are the most powerful pain relievers available and are very effective, but they carry the risk of serious side effects as well as the potential for addiction and must be used under a doctor's supervision. This step is typically reserved for moderate to severe pain that has not been controlled by OTC or other non-opioid prescription medications.