Final answer:
Oxycodone is unsafe for the central nervous system as a supplement to epidural anesthesia due to its addictive and potentially harmful nature.
Step-by-step explanation:
The drug that is unsafe for the central nervous system as a supplement to epidural anesthesia is Oxycodone.
Oxycodone is a prescription pain reliever that belongs to the class of opioids. While it can be effective in managing pain, it carries serious risks of addiction, abuse, and overdose. Additionally, opioids, including Oxycodone, can have several side effects on the central nervous system.
It is important to consult a healthcare professional for the appropriate use of medication with epidural anesthesia.