Final answer:
The best initial statement for the nurse to make in the assessment phase of a 49-year-old client experiencing problems with depression, malnutrition, and fatigue is to ask about the weight loss over the past month.
Step-by-step explanation:
The best initial statement for the nurse to make in the assessment phase of a 49-year-old client experiencing problems with depression, malnutrition, and fatigue would be option 1, "How much weight have you lost over the past month?" This question helps to assess the client's nutritional status and if there has been any significant weight loss, which is associated with depression.