Question

Which of the following drug properties are focused on during the optimization of initial hits (leads) from a drug screen?

a) Drug safety
b) Drug target specificity
c) Drug pharmacokinetics
d) Drug discovery

Answer 1

During the optimization of initial hits (leads) from a drug screen, the focus is on drug safety, drug target specificity, and drug pharmacokinetics.

Step-by-step explanation:

The optimization of initial hits (leads) from a drug screen focuses on several drug properties:

1. Drug safety: The candidate drugs should have minimal toxicity and side effects.
2. Drug target specificity: The drugs should specifically target the protein or molecule associated with the disease.
3. Drug pharmacokinetics: This includes the absorption, distribution, metabolism, and excretion (ADME) properties of the drugs, such as solubility, bioavailability, and metabolic stability.