Final answer:
Collagen and hyaluronan synthase are necessary for the production of the HA-rich ECM in tumors.
Step-by-step explanation:
The production of the hyaluronic acid (HA)-rich extracellular matrix (ECM) in tumors is dependent on collagen and hyaluronan synthase. Collagens are a major component of the ECM, providing structure and support. Hyaluronan synthase is responsible for synthesizing hyaluronic acid, which is a major component of the HA-rich ECM in tumors.