Final answer:
During the ADME phase of drug development, the primary factors analyzed are Absorption, Distribution, Metabolism, and Excretion, as they are integral to understanding a drug's pharmacokinetics.
Step-by-step explanation:
The aspects analyzed during the ADME phase of drug development are Absorption, Distribution, Metabolism, and Excretion. These factors are crucial because they determine the drug's bioavailability, its duration of action, and potential side effects. Various in vitro and in vivo model systems are employed in the early stages of drug discovery to assess these pharmacokinetic properties. This evaluation includes, but is not limited to, determinations of apparent permeability, plasma protein binding, liver microsomal stability, and identification of reactive metabolites.