Final answer:
In the case of a patient with pyelonephritis who shows no clinical response within 48-72 hours of oral meds, further imaging studies should be considered to identify any underlying issues. Increasing oral fluid intake may also be beneficial. Surgery or a different class of antibiotics would not typically be required without further investigation.
Step-by-step explanation:
In the case of a patient with pyelonephritis who shows no clinical response within 48-72 hours of oral meds, further imaging studies should be considered. This is because imaging of the kidneys can help identify any obstruction or other complications that may be causing the lack of response to treatment. It is important to rule out these underlying issues before considering other treatment options.
Increasing oral fluid intake may also be beneficial as it helps flush out the bacteria causing the infection. However, this alone may not be sufficient if there are other underlying issues contributing to the lack of response.
Immediate surgery or a different class of antibiotics would typically not be required without further investigation through imaging studies.