Final answer:
The most common route of spread for endometrial cancer is lymphatic spread, in which cancer cells travel to regional lymph nodes. Other forms of cancer spread include local invasion and hematogenous spread, which is through the blood to distant organs.
Step-by-step explanation:
The most common route of spread of endometrial cancer is lymphatic spread. This involves cancer cells traveling from the primary tumor in the endometrium to nearby lymph nodes through the lymphatic system. The lymphatic system is frequently involved in the regional dissemination of cancer cells, which precedes the involvement of more distant sites.
There are several ways cancer can spread from its original site to other parts of the body. Local spread, where cancer invades nearby tissues, and hematogenous spread, with cancer cells traveling through the blood to distant sites, are other forms of metastasis. However, for endometrial cancer, lymphatic dissemination remains the most common initial pathway of spread before potentially metastasizing to distant organs.