163k views
2 votes
Multitarget single hit model dose response curve equation?

1 Answer

3 votes

Final answer:

The multi target single hit model follows a linear dose-response relationship, represented by y = mx + b, and is important for assessing biological systems' responses to radiation doses.

Step-by-step explanation:

The multi target single hit model is used to describe the response of biological systems to doses of radiation. According to this model, the dose-response curve follows a linear relationship, which can be represented by the equation similar to the straight-line equation y = mx + b.

When plotting the natural logarithm of the activity (ln A) against the time (t), a linear plot is expected with the slope represented by the negative decay constant and the y-intercept given by ln A0, being A0 the initial activity. The activity of a radioactive substance is measured in becquerels (Bq), with one Bq equaling one decay per second, and can also be compared to the curie (Ci), where 1 Ci = 3.70 × 1010 Bq.

The dose-response evaluation is essential for determining dose proportionality and assessing the margin of safety based on the efficacy concentration and exposure data obtained from toxicokinetic studies.

User RNHTTR
by
7.4k points