Question

What factors implicate a monoclonal origin for tumors?

a.Genetic Homogeneity
b.Clonal Evolution:
c.Common Ancestral Mutations
d.Molecular Profiling Consistency

Answer 1

Factors that implicate a monoclonal origin for tumors include genetic homogeneity, clonal evolution, common ancestral mutations, and molecular profiling consistency.

Step-by-step explanation:

Several factors implicate a monoclonal origin for tumors:

1. Genetic Homogeneity: Tumors that arise from a single cell will have genetic uniformity because the cells are clones of each other.
2. Clonal Evolution: As tumors grow, genetic changes may occur, resulting in the development of subclones within the tumor.
3. Common Ancestral Mutations: The presence of specific mutations in all tumor cells suggests a monoclonal origin.
4. Molecular Profiling Consistency: Molecular profiling techniques can reveal consistent patterns of gene expression or mutation across different tumor cells, indicating a monoclonal origin.