Final answer:
An aberrant increase in cyclins or a decrease in CDKIs correlates with differentiated state and tumor aggressiveness.
Step-by-step explanation:
True. An aberrant increase in cyclins or a decrease in CDKIs (Cyclin-Dependent Kinase Inhibitors) is associated with a differentiated state and tumor aggressiveness. Cyclins play a crucial role in regulating the cell cycle by binding to and activating CDKs, which in turn phosphorylate target proteins to promote cell cycle progression. If cyclin levels remain high or CDKIs are reduced, the cell cycle can become dysregulated, leading to uncontrolled cell division and the development of more aggressive tumors.