Final answer:
Tolerance induction to non-self antigens is beneficial for preventing unnecessary or harmful immune responses and autoimmune diseases, and for maintaining mucosal homeostasis. It is crucial for modulating the immune system during organ transplants and also plays a role in controlling peripheral and central immune tolerance.
Step-by-step explanation:
Tolerance induction to certain non-self antigens is beneficial when it prevents an unnecessary or harmful immune response to a substance that is known not to cause disease, or to self-antigens. One major benefit of immune tolerance is the ability to maintain homeostasis, particularly in mucosal tissues exposed to a vast array of foreign substances. This is achieved through the action of regulatory T (Treg) cells and specialized antigen-presenting cells (APCs), which together prevent autoimmune diseases by suppressing harmful immune responses. An example of the need for immune tolerance is during organ transplantation, where immune responses against the transplanted tissue must be controlled. Additionally, other forms of tolerance such as peripheral tolerance and central tolerance are essential for preventing autoimmunity and maintaining the balance within the immune system.