Question

Thiazide inhibits ___ in distal tubule. What does this ultimately do?

a. NCC; limits NaCl absorption, which limits H2O reabsorption, which lowers blood volume, which lowers blood pressure.
b. Aquaporins; enhances water reabsorption, which increases blood volume, which raises blood pressure.
c. Aldosterone; increases sodium reabsorption, which enhances water retention, which raises blood pressure.
d. Glomerular filtration; reduces filtration rate, which decreases blood volume, which lowers blood pressure.

Answer 1

Thiazides inhibit the sodium-chloride transporter (NCC) in the kidney's distal convoluted tubule, reducing NaCl and water reabsorption, thereby lowering blood volume and blood pressure.

Step-by-step explanation:

The correct answer to the question 'Thiazide inhibits ___ in the distal tubule. What does this ultimately do?' is: a. NCC; limits NaCl absorption, which limits H2O reabsorption, which lowers blood volume, which lowers blood pressure. Thiazides are a class of diuretics that inhibit the sodium-chloride transporter (NCC) in the distal convoluted tubule of the kidney. This inhibition results in decreased reabsorption of sodium and chloride, which leads to less water being reabsorbed by the kidneys. As a consequence of this reduced water reabsorption, blood volume decreases, which ultimately leads to a reduction in blood pressure.