Question

In the absence of HPRT activity, ____________ is converted to excess____ ____ = crystals that deposit in the joints and trigger painful inflammation. Examples are _____ and _____________, an X-linked neurological disorder.

a. Hypoxanthine; uric acid; Gout; Lesch-Nyhan Syndrome or LNS.
b. Adenosine; guanine; Arthritis; Huntington's Disease.
c. Thymidine; cytosine; Osteoporosis; Alzheimer's Disease.
d. Cytosine; thymidine; Rheumatoid Arthritis; Parkinson's Disease.

Answer 1

In the absence of HPRT activity, hypoxanthine is converted to excess uric acid, leading to conditions such as gout and Lesch-Nyhan Syndrome (LNS).

Step-by-step explanation:

In the absence of HPRT activity, hypoxanthine is converted to excess uric acid, which forms crystals that deposit in the joints and trigger painful inflammation. Examples of conditions related to HPRT deficiency are gout and Lesch-Nyhan Syndrome (LNS), an X-linked neurological disorder. Therefore, the correct answer is: a. Hypoxanthine; uric acid; Gout; Lesch-Nyhan Syndrome or LNS.