Question

Which of the theses features would you expect to find in a sample taken from a patient with ataxia-telangiectasia? a) Reduced transcription of P21

b) Increased transcription of P21
c) Unchanged transcription of P21
d) Absence of P21 in the sample

Answer 1

In a sample from a patient with ataxia-telangiectasia, you would expect to find reduced transcription of P21 due to the mutation in the ATM gene.

Step-by-step explanation:

In a sample taken from a patient with ataxia-telangiectasia, you would expect to find reduced transcription of P21. This is because ataxia-telangiectasia is a genetic disorder caused by a mutation in the ATM gene, which leads to a decrease in the activity of the ATM protein. The ATM protein normally plays a role in activating p53, a transcription factor that induces the expression of P21, a cell cycle inhibitor. Therefore, with reduced ATM activity, there would be reduced transcription of P21.