Question

A patient comes in with signs and symptoms of neurodegeneration. What is the cause of this disorder? a) Excessive stimulation by glutamate

b) Insufficient neurotransmitter release
c) Neurotransmitter reuptake dysfunction
d) Abnormalities in ion channel function

Answer 1

Excessive stimulation by glutamate is a common cause of neurodegeneration, leading to excitotoxicity and neuronal death.

Step-by-step explanation:

Neurodegeneration can be caused by various factors, but one common cause is excessive stimulation by glutamate. Glutamate is an excitatory neurotransmitter that plays a crucial role in brain function. However, when there is an over-activation of glutamate receptors, it can lead to an excessive influx of calcium ions into neurons, causing excitotoxicity and eventual neuronal death. This mechanism has been implicated in various neurodegenerative diseases such as stroke, Alzheimer's, Parkinson's, and others.