Final Answer:
Isoniazid could create a physiologic response that would be a major source of free-radical production
Therefore, correct answer is (B) Isoniazid.
Step-by-step explanation:
Chronic administration of isoniazid can lead to the formation of free radicals.
Isoniazid, a medication commonly used to treat tuberculosis, undergoes metabolic activation through the hepatic enzyme N-acetyltransferase. This process can result in the formation of reactive intermediates, particularly hydrazine and acetylhydrazine. These reactive metabolites can lead to hepatotoxicity and neurotoxicity.
The generation of free radicals during this metabolic pathway is a major source of oxidative stress in the body. In contrast, ciprofloxacin, cimetidine, and ketoconazole do not undergo similar metabolic activation to produce free radicals in significant amounts. Therefore, among the options provided, isoniazid is the medication most likely to create a physiologic response resulting in substantial free-radical production.
Therefore, correct answer is (B) Isoniazid.