Question

P53 tumor suppressor G1 checkpoint (Step 1):

a) DNA damage occurs, checkpoint-specific protein kinases phosphorylate and stabilize p53.
b) Check for adequate nutrient supply
c) Check for cell size
d) Check for proper chromosome alignment

Answer 1

The p53 tumor suppressor protein plays a critical role in the G1 checkpoint of the cell cycle by checking for DNA damage, proper chromosome alignment, adequate nutrient supply, and cell size.

Step-by-step explanation:

The p53 tumor suppressor protein plays a critical role in the G1 checkpoint of the cell cycle. When DNA damage occurs during G1, checkpoint-specific protein kinases phosphorylate and stabilize p53.

One of the functions of p53 at the G1 checkpoint is to check for proper chromosome alignment in cells undergoing preparatory processes during G1.

The p53 protein also checks for adequate nutrient supply and cell size before allowing the cell to proceed from G1 to the S phase of the cell cycle.