Final answer:
The patient with hypertension and proteinuria is at the greatest risk of developing ESKD.
Step-by-step explanation:
The nurse knows that the patient with hypertension and proteinuria is at the greatest risk of developing End-Stage Kidney Disease (ESKD). Hypertension and proteinuria are both common risk factors for the development of ESKD. Hypertension can lead to damage to the blood vessels in the kidneys, while proteinuria is a sign of kidney damage.