Final answer:
Rough endoplasmic reticulum is studded with ribosomes and is involved in protein synthesis. Smooth endoplasmic reticulum does not have any ribosomes and is involved in lipid synthesis and drug detoxification.
Step-by-step explanation:
Rough endoplasmic reticulum (RER) is studded with ribosomes, which gives it a "rough" appearance. These ribosomes make proteins that are then transported from the ER in small sacs called transport vesicles. The rough ER works with the Golgi apparatus to move new proteins to their proper destinations in the cell. The smooth endoplasmic reticulum (SER) does not have any ribosomes attached to it and has a smooth appearance. It has functions such as lipid synthesis, calcium ion storage, and drug detoxification.