Final answer:
The nurse should first submerge the end of the tube in sterile water to create a water seal and prevent air from entering the patient's chest cavity.
Step-by-step explanation:
The nurse should first submerge the end of the tube in sterile water. This should be done to prevent air from entering the patient's chest cavity and causing a pneumothorax, which is a potentially life-threatening condition. Submerging the tube in sterile water creates a water seal that prevents air from entering the system.