Final answer:
The nurse should inform the client to discontinue NSAIDs while taking misoprostol in order to maximize the benefits of the medication and avoid potential interactions.
Step-by-step explanation:
The nurse should provide the client with the information to discontinue NSAIDs while taking misoprostol. Misoprostol is commonly used to protect the stomach lining from the damaging effects of NSAIDs by reducing the risk of stomach ulcers and gastrointestinal bleeding. Therefore, it is important for the client to stop taking NSAIDs and only take misoprostol to avoid potential interactions and maximize the benefits of the medication.