Final answer:
The foundation with the largest portfolio in global health is the Bill & Melinda Gates Foundation. The foundation focuses on improving global health, particularly in developing countries through vaccinations and poverty alleviation, and in the U.S. through education reform.
Step-by-step explanation:
The foundation with the largest portfolio in global health is B) Bill & Melinda Gates Foundation. Private philanthropists like the Gates Foundation have been pivotal in addressing global health issues. Founded in 2000, the foundation expanded its efforts in 2020 to focus on critical areas of global health, alongside its educational initiatives.
With a mission statement that emphasizes that every life has equal value, the Bill & Melinda Gates Foundation is dedicated to helping people lead healthy, productive lives. They are notably attentive to improving public health in developing countries by providing vaccines and essential tools, as well as efforts to alleviate hunger and poverty. In the U.S., their focus is significantly on improving education. The foundation's leadership team, headed by CEO Jeff Raikes and co-chairs William H. Gates Sr. and under the guidance of Bill and Melinda Gates and Warren Buffett, operates from Seattle, Washington.