Final answer:
The nurse should instruct the patient to: 1) avoid combining acetaminophen with alcohol, 2) take acetaminophen with meals to prevent gastric irritation, and 3) understand that physical dependence may occur with long-term use.
Step-by-step explanation:
Instructions for Long-term Acetaminophen Use
- Caution the patient against combining acetaminophen with alcohol: Acetaminophen and alcohol can both affect the liver, and combining the two can increase the risk of liver damage.
- Advise taking acetaminophen with meals to prevent gastric irritation: Taking acetaminophen with food can help reduce the risk of stomach upset.
- Explain that physical dependence may occur with long-term oral use: While acetaminophen is not known to be physically addictive, it is important for the patient to be aware that long-term use may lead to dependence or tolerance.