Question

Variation in which familial hypercholesterolemia-causing gene has also been associated with protection from coronary artery disease and high cholesterol levels in general populations?

A LDL receptor (LDLR)
B PCSK9 protease
C Apoprotein B-100 (ApoB100)
D ARH adaptor protein (ARH)
E All of the above

Answer 1

The PCSK9 protease gene is associated with protection from coronary artery disease and high cholesterol, as variations in this gene can result in lower levels of LDL cholesterol.

Step-by-step explanation:

The variation in the gene associated with protection from coronary artery disease and high cholesterol levels in general populations is in the PCSK9 protease (Option B). This gene plays a critical role in the regulation of cholesterol levels by degrading the LDL receptor, which is responsible for removing LDL-cholesterol from the bloodstream. Certain mutations in PCSK9 can lead to lower levels of LDL cholesterol and consequently a lower risk of coronary artery disease.