Question

Using the following groups, compose a formula for the odds ratio for a disease-marker association.a. Affecteds who have marker allele of interestb. Affecteds who lack the marker allele of interestc. Controls who have the marker allele of interestd. Controls who lack the marker allele of interest

A ab/cd
B ac/bd
C ad/bc
D cd/ab
E cb/ad

Answer 1

The correct formula for the odds ratio using the groups provided is C: ad/bc, where each letter represents a specific group related to both the presence of a disease and the presence of a marker allele.

Step-by-step explanation:

The question asks us to compose a formula for the odds ratio for a disease-marker association using different groups. The odds ratio is a measure used in epidemiology to determine the strength of the association between exposure (in this case, having the marker allele) and an outcome (being affected by the disease).

Based on the groups provided, the correct formula for the odds ratio (OR) is:

OR = (a * d) / (b * c)

• a = Affecteds who have the marker allele of interest
• b = Affecteds who lack the marker allele of interest
• c = Controls who have the marker allele of interest
• d = Controls who lack the marker allele of interest

The answer is therefore, C: ad/bc, which correlates to the product of the odds of the event occurring in exposed individuals by the odds of the event occurring in non-exposed individuals.