Question

Four sites associated with what type of DNA conformation are important for the regulatory control of β globin expression by the locus control region (LCR)?

A Open chromatin conformation
B Closed chromatin conformation
C DNA hairpin
D DNA break
E DNA loop

Answer 1

The four sites important for the regulatory control of β globin expression by the LCR are associated with an open chromatin conformation, allowing transcription factors and RNA polymerase to access DNA.

Step-by-step explanation:

The four sites associated with the regulatory control of β globin expression by the locus control region (LCR) are important for an open chromatin conformation. This open chromatin conformation is necessary for the appropriate proteins and regulatory factors to bind to DNA and initiate transcription. Enhancers, which are part of the LCR, bind transcription factors that help to open up the chromatin, allowing for the gene to be transcribed. The opening of chromatin is facilitated through the addition of different chemical groups to histones and DNA, resulting in a less compact and more accessible form of DNA for transcription factors and RNA polymerase II.