Final answer:
Telocentric chromosomes, with the centromere at the very end, are not present in a normal human karyotype. Human chromosomes may be metacentric, submetacentric, or acrocentric.
Step-by-step explanation:
The option that is not seen in a normal human karyotype is E) Telocentric chromosomes. In humans, chromosomes can be classified based on the location of the centromere, leading to different chromosome shapes. We have metacentric chromosomes where the centromere is approximately in the middle, leading to arms of roughly equal length; submetacentric chromosomes, which have an off-center centromere creating one arm slightly longer than the other; and acrocentric chromosomes, where the centromere is near one end, creating a long arm and a very short arm with satellite DNA. However, telocentric chromosomes, which have the centromere at the very end of the chromosome, are not found in normal human cells.