Final answer:
When taking a systemic antifungal drug, the patient should report signs of unusual bruising and bleeding to the provider immediately, as this could indicate a serious complication.
Step-by-step explanation:
The nurse instructing a patient on the signs or symptoms to report immediately when taking a newly prescribed systemic antifungal drug should emphasize the importance of identifying and communicating any unusual bruising and bleeding. This symptom can indicate a potentially serious complication such as compromised blood clotting or other hematological issues. It is essential for the patient to be aware that while antifungal drugs like amphotericin B and flucytosine are effective at treating fungal infections, they can have side effects that require prompt medical attention, including jaundice, mucosal hemorrhaging, and severe systemic responses.